… modification according to predicted quality of INR control, we … regression model for outcome,
including all patients. We did not … : stroke or systemic embolism (primary efficacy outcome), …

… ratios, confidence intervals, and P values for different events during follow-up. When comparing
apixaban with warfarin … the numbers needed to treat to prevent one event per 100 patient …

… Efficacy and safety of apixaban compared with warfarin at different levels of predicted
international normalized ratio control for stroke prevention in atrial fibrillation.Circulation. 2013; 127…

… of apixaban in comparison with warfarin were similar across different levels of centers’ and
patients’ predicted … and at least one risk factor for stroke. Participants were randomized to …

… to the trials of dabigatran, 20 apixaban, 21 and edoxaban. ROCKET-AF had … level comparisons
showed that DOACs had greater margins of efficacy and safety at sites with high control …

… with warfarin despite a similar level of international normalized ratio (INR) control.5, 6 …
factors in the development of better prediction scores for stroke in patients with AF. Even in …

… ) in the comparator (warfarin) arm was different in the four trials, … the other three trials had
better international normalized ratio … Anticoagulation control and prediction of adverse events in …

… ) for the prevention of stroke in nonvalvular atrial fibrillation (AF… 7 HAS-BLED score—International
Normalized Ratio (INR), 8 a … HAS-BLED score is a validated prediction measure for the …

… across the range of centres' and patients' predicted quality of INR control. Our data confirm
these findings in patients ≥75 years of age. In these elderly patients, a greater reduction in …

… , stroke, bleeding history, labile international normalized ratio, … also predict a higher bleeding
risk in patients taking warfarin, … a larger variability in international normalized ratio control. …